Stroke Hemorrhagic after Snakebite: A Scoping Review
Keywords:
Bohtropp spp; Cerebral complication; Hemorrhagic; Snakebite; Stroke,Abstract
Snakebite envenomation is a neglected tropical disease that affects millions of individuals living in underdeveloped countries. Cerebral complications are often found in venomous snake bite victims. Certain snake venoms can interfere with the blood's ability to clot, increasing the risk of bleeding in the brain and potentially causing a stroke. previous literature review studies have not comprehensively reviewed stroke hemorrhagic after snake bites. Therefore, we are interested in conducting a literature review using the scoping review method on stroke hemorrhagic after snake bites. The samples in this study were published articles from international journals related to cerebral complications after snakebite that met the inclusion and exclusion criteria. The inclusion criteria used in this study were articles derived from the PubMed, ScienceDirect, and Scopus databases, using the keywords “Snakebite” OR “Snake envenoming” AND “Stroke hemorrhagic”. Based on the eligibility, Six articles were finally synthesized in the study. All of papers were a case report design. Three cases were from Brazil, three cases from Morocco, Burkina Faso and Togo. The snake that causes hemorrhagic stroke in Brazil is Bothropp spp. however, the type of snake in the instances from Burkina Faso and Morocco is unknown. There were a total of 10 instances reported from 6 journals. One patient from Morocco died, while another patient from Brazil suffered from prolonged hemiplegia. Furthermore, a total of 8 more patients were released from the hospital in an improved condition.
References
Bagcchi S. Experts call for snakebite to be re-established as a neglected tropical disease. Published online 2015. https://www.bmj.com/content/351/bmj.h5313.abstract
World Health Organization. (2016). Guidelines for the Management of Snakebites. eprints.triatmamulya.ac.id; 2016. https://eprints.triatmamulya.ac.id/1536/1/Guideline Management for snake bite.pdf
Pandey DP, Thapa CL, Hamal PK. Impact of first aid training in management of snake bite victims in Madi valley. J Nepal Health Res Counc. 2010;8(1):5-9.
David S, Matathia S, Christopher S. Mortality Predictors of Snake Bite Envenomation in Southern India-A Ten-Year Retrospective Audit of 533 Patients. J Med Toxicol. 2012;8(2):118-123. doi:10.1007/s13181-011-0204-0
Isbister GK. Antivenom availability, delays and use in Australia. Toxicon X. 2023;17. doi:10.1016/j.toxcx.2022.100145
Stephen E. Meyers; Prasanna Tadi. Snake Toxicity. Published 2022. https://www.ncbi.nlm.nih.gov/books/NBK557565/
Munawar A, Ali SA, Akrem A, Betzel C. Snake Venom Peptides: Tools of Biodiscovery. Toxins (Basel). 2018;10(11). doi:10.3390/toxins10110474
Huang Y-K, Chen Y-C, Liu C-C, Cheng H-C, Tu AT, Chang K-C. Cerebral Complications of Snakebite Envenoming: Case Studies. Toxins (Basel). 2022;14(7). doi:10.3390/toxins14070436
Talukdar A, Maddhesiya P, Namsa ND, Doley R. Snake venom toxins targeting the central nervous system. Toxin Rev. 2023;42(1):382-406.
Dey A, De JN. Traditional use of plants against snakebite in indian subcontinent: A review of the recent literature. African J Tradit Complement Altern Med. 2012;9(1). doi:10.4314/ajtcam.v9i1.20
Kuch U, Sharma SK, Alirol E, Chappuis F. Fatal neurotoxic envenomation from the bite of a lesser Black Krait (Bungarus Lividus) in Nepal. Southeast Asian J Trop Med Public Health. 2011;42(4):960-964. https://www.scopus.com/inward/record.uri?eid=2-s2.0-80054944243&partnerID=40&md5=772d432e78c86932665d649829caa4f2
Menon JC, Joseph JK. Complications of hemotoxic snakebite in India. In: Toxinology: Clinical Toxinology in Asia Pacific and Africa. ; 2015:209-232. doi:10.1007/978-94-007-6386-9_22
Chérifi F, Laraba-Djebari F. Bioactive molecules derived from snake venoms with therapeutic potential for the treatment of thrombo-cardiovascular disorders associated with COVID-19. Protein J. Published online 2021:1-43.
Ghosh R, León-Ruiz M, Roy D, Naga D, Sardar SS, Benito-León J. Cerebral venous sinus thrombosis following Russell’s viper (Daboia russelii) envenomation: A case report and review of the literature. Toxicon. 2022;218:8-12. doi:10.1016/j.toxicon.2022.08.014
Pérez-Gómez AS, Monteiro WM, João GAP, et al. Hemorrhagic stroke following viper bites and delayed antivenom administration: Three case reports from the western Brazilian Amazon. Rev Soc Bras Med Trop. 2019;52. doi:10.1590/0037-8682-0115-2019
Pinzon RT, Antonius RA, Veronica V. Ischemic Stroke Following Calloselasma rhodostoma Snakebite: A Rare Case Report. Open Access Emerg Med. 2022;14:35-39. doi:10.2147/OAEM.S352865
Kumar RM, Babu RP, Agrawal A. Multiple infarctions involving cerebral and cerebellar hemispheres following viper bite. JMS - J Med Soc. 2015;29(1):51-53. doi:10.4103/0972-4958.158938
Magalhães SF V, Peixoto HM, de Freitas LRS, Monteiro WM, de Oliveira MRF. Snakebites caused by the genera Bothrops and Lachesis in the Brazilian Amazon: a study of factors associated with severe cases and death. Rev Soc Bras Med Trop. 2022;55. doi:10.1590/0037-8682-0558-2021
Del Brutto OH, Del Brutto VJ. Neurological complications of venomous snake bites: A review. Acta Neurol Scand. 2012;125(6):363-372. doi:10.1111/j.1600-0404.2011.01593.x
Naik SB. Intravenous snake bite: A catastrophic snake envenomation. Ann Afr Med. 2023;22(3):239-245. doi:10.4103/aam.aam_9_23
Gasanov SE, Dagda RK, Rael ED. Snake Venom Cytotoxins, Phospholipase A2s, and Zn2+-dependent Metalloproteinases: Mechanisms of Action and Pharmacological Relevance. J Clin Toxicol. 2014;4(1):1000181.
Resiere D, Mehdaoui H, Neviere R. Inflammation and oxidative stress in snakebite envenomation: a brief descriptive review and clinical implications. Toxins (Basel). 2022;14(11):802.
Larréché S, Chippaux J-P, Chevillard L, et al. Bleeding and thrombosis: Insights into pathophysiology of Bothrops venom-related hemostasis disorders. Int J Mol Sci. 2021;22(17):9643.
Ranawaka UK, Lalloo DG, de Silva HJ. Neurotoxicity in Snakebite-The Limits of Our Knowledge. PLoS Negl Trop Dis. 2013;7(10). doi:10.1371/journal.pntd.0002302
Chaudhary SC, Sawlani KK, Malhotra HS, Singh J. Snake bite-induced leucoencephalopathy. BMJ Case Rep. Published online 2013. doi:10.1136/bcr-2012-007515
Ahmed SM, Khan M, Zaka-Ur-Rab Z, Nadeem A, Agarwal S. Hypertensive encephalopathy following snake bite in a child: A diagnostic dilemma. Indian J Crit Care Med. 2013;17(2):111-112. doi:10.4103/0972-5229.114819
Dabilgou AA, Sondo A, Dravé A, et al. Hemorrhagic stroke following snake bite in Burkina Faso (West Africa). A case series. Trop Dis Travel Med vaccines. 2021;7(1):1-6.
Al-Sadawi M, Mohamadpour M, Zhyvotovska A, et al. Cerebrovascular accident and snake envenomation: a scoping study. Int J Clin Res trials. 2019;4.
Hawa KA, Mhaili J, Boutakioute B, Idrissi MO, El Ganouni NI. Hemorrhagic stroke revealing a snake bite: A case report. Cureus. 2022;14(1).
de Oliveira Pardal PP, da Silva Pinheiro ACJ, Cunha Silva CT, Santos PRSG, da Costa Gadelha MA. Hemorrhagic stroke in children caused by Bothrops marajoensis envenoming: A case report. J Venom Anim Toxins Incl Trop Dis. 2015;21(1). doi:10.1186/s40409-015-0052-5
Sachett J de AG, Mota da Silva A, Dantas AWCB, et al. Cerebrovascular Accidents Related to Snakebites in the Amazon—Two Case Reports. Wilderness Environ Med. 2020;31(3):337-343. doi:https://doi.org/10.1016/j.wem.2020.04.009
Delgado ABT, Gondim CCVL, Reichert LP, et al. Hemorrhagic stroke secondary to Bothrops spp. venom: A case report. Toxicon. 2017;132:6-8. doi:https://doi.org/10.1016/j.toxicon.2017.03.015
Kumako VK, N’timon B, Apetse K, et al. Two cases of hemorrhagic stroke following Snake bite in Kara teaching Hospital in a Semi Rural Area in Togo. Sci J Neurol Neurosurg. 2018;4(1):1-4.
Schneider MC, Min K, Hamrick PN, ... Overview of snakebite in Brazil: Possible drivers and a tool for risk mapping. PLoS neglected …. Published online 2021. https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0009044
Kini RM, Koh CY. Metalloproteases Affecting Blood Coagulation, Fibrinolysis and Platelet Aggregation from Snake Venoms: Definition and Nomenclature of Interaction Sites. Toxins (Basel). 2016;8(10). doi:10.3390/toxins8100284
Mosquera A, Idrovo LA, Tafur A, Del Brutto OH. Stroke following Bothrops spp. snakebite. Neurology. 2003;60(10):1577-1580.
Chaves F, Barboza M, Gutiérrez J. Pharmacological study of edema induced by venom of the snake Bothrops asper (terciopelo) in mice. Toxicon. 1995;33(1):31-39. doi:https://doi.org/10.1016/0041-0101(94)00135-U
Péterfi O, Boda F, Szabó Z, Ferencz E, Bába L. Hypotensive Snake Venom Components-A Mini-Review. Molecules. 2019;24(15). doi:10.3390/molecules24152778
Sarkar S, Sinha R, Chaudhury AR, et al. Snake bite associated with acute kidney injury. Pediatr Nephrol. 2020;36(12):3829-3840. doi:10.1007/s00467-020-04911-x
Hou Y-T, Chang M-C, Yang C, et al. Prediction of Compartment Syndrome after Protobothrops mucrosquamatus Snakebite by Diastolic Retrograde Arterial Flow: A Case Report. Med. 2022;58(8). doi:10.3390/medicina58080996
Rajagopala S, Thabah MM, Ariga KK, Gopalakrishnan M. Acute hypopituitarism complicating Russell’s viper envenomation: Case series and systematic review. QJM. 2015;108(9):719-728. doi:10.1093/qjmed/hcv011
Tsai I-H, Wang Y-M, Cheng AC, et al. cDNA cloning, structural, and functional analyses of venom phospholipases A2 and a Kunitz-type protease inhibitor from steppe viper Vipera ursinii renardi. Toxicon. 2011;57(2):332-341. doi:https://doi.org/10.1016/j.toxicon.2010.12.012
Teixeira C, Fernandes CM, Leiguez E, Chudzinski-Tavassi AM. Inflammation Induced by Platelet-Activating Viperid Snake Venoms: Perspectives on Thromboinflammation. Front Immunol. 2019;10. doi:10.3389/fimmu.2019.02082
Oliveira AL, Viegas MF, da Silva SL, Soares AM, Ramos MJ, Fernandes PA. The chemistry of snake venom and its medicinal potential. Nat Rev Chem. 2022;6(7):451-469. doi:10.1038/s41570-022-00393-7
Zeng X, Hu J, Liang X, et al. Acute cerebral infarction following a Trimeresurus stejnegeri snakebite: A case report. Med (United States). 2019;98(23). doi:10.1097/MD.0000000000015684
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