Utilization of Xpert MTB/RIF molecular test and Thorax Radiography as Tuberculosis Screening at PKU Muhammadiyah Bantul Hospital

Authors

  • Elvina Prisila Universitas Ahmad Dahlan, Yogyakarta, Indonesia
  • Novi Wijayanti Sukirto Universitas Ahmad Dahlan, Yogyakarta, Indonesia
  • Nurcholid Umam Kurniawan Universitas Ahmad Dahlan, Yogyakarta, Indonesia
  • Ana Budi Rahayu Universitas Ahmad Dahlan, Yogyakarta, Indonesia
  • Dewi Yuniasih Universitas Ahmad Dahlan, Yogyakarta, Indonesia
  • Ardyawati Wira Oktaviana Universitas Ahmad Dahlan, Yogyakarta, Indonesia
  • Febrianti Putri Nurulita Universitas Ahmad Dahlan, Yogyakarta, Indonesia
  • Amanatus Sholikhah Universitas Ahmad Dahlan, Yogyakarta, Indonesia
  • Wiwara Awisarita Universitas Ahmad Dahlan, Yogyakarta, Indonesia

Keywords:

Thorax radiology; XPERT MTB/RIF molecular test; Rapid diagnosis,; Tuberculosis

Abstract

Tuberculosis is a disease caused by the bacteria Mycobacterium tuberculosis, and approximately 25% of the global population is afflicted with this bacterium. In 2022,The objective of this study is to assess the effectiveness of the Xpert MTB/RIF Molecular Test and Thorax Radiography as diagnostic tools for tuberculosis at PKU Muhammadiyah Bantul Hospital. The research employed quantitative methodologies with a cross-sectional design.  The majority of tuberculosis suspects at PKU Muhammadiyah Bantul Hospital were individuals aged 64 years or older, based on age group. In terms of gender, 498 individuals were male. According to the Xpert MTB/RIF molecular test, 89 individuals tested positive for tuberculosis. In contrast, the number of individuals who tested positive for tuberculosis through thorax photo examination was 184. The findings indicate that the majority of patients suspected of having Tuberculosis were males and were primarily in the age category of above 64 years old. Thorax photo radiography yielded a higher number of confirmed positive tuberculosis findings compared to the Xpert MTB/RIF molecular test, based on the evaluation of individuals suspected of having tuberculosis.

References

World Health Organization. Tuberculosis. https://www.who.int/health-topics/tuberculosis#tab=tab_1

Patterson B, Wood R. Is cough really necessary for TB transmission? Tuberculosis (Edinb). 2019;117:31-35. doi:10.1016/j.tube.2019.05.003

Gralton J, Tovey E, McLaws M-L, Rawlinson WD. The role of particle size in aerosolised pathogen transmission: a review. J Infect. 2011;62(1):1-13.

Loudon RG, Roberts RM. Singing and the dissemination of tuberculosis. Am Rev Respir Dis. 1968;98(2):297-300.

WHO. World Health Organization South-East Asia Indonesia: TB Day 2022.

Villar-Hernández R, Ghodousi A, Konstantynovska O, Duarte R, Lange C, Raviglione M. Tuberculosis: current challenges and beyond. Breathe (Sheffield, England). 2023;19(1):220166. doi:10.1183/20734735.0166-2022

Kemenkes RI. Profil Kesehatan Indonesia 2020.; 2021.

Kemenkes RI. Profil Kesehatan Indonesia 2022.; 2023.

Dinkes Kabupaten Bantul. Profil Kesehatan Kabupaten Bantul 2022.; 2023.

Dinkes Kabupaten Bantul. Profil Kesehatan Bantul 2021. Dinkes Kabupaten Bantul; 2022.

Laily DW, Rombot D V., Lampus BS. Karakteristik pasien Tuberkulosis Paru di Puskesmas Tuminting Manado. J Kedokt Komnitas dan Trop. 2015;3(1):1-5.

Lestari NPWA, Dedy MAE, Artawan IM, Buntoro IF. Perbedaan Usia Dan Jenis Kelamin Terhadap Ketuntasan Pengobatan Tb Paru Di Puskesmas Di Kota Kupang. Cendana Med J. 2022;10(1):24-31.

Sunarmi S, Kurniawaty K. Hubungan Karakteristik Pasien Tb Paru Dengan Kejadian Tuberkulosis. J ’Aisyiyah Med. 2022;7(2):182-187. doi:10.36729/jam.v7i2.865

Kemenkes RI. Pedoman Nasional Pelayanan Kedokteran Tata Laksana Tuberkulosis.; 2020.

Moree T, Lawrence H. Crash Course Kedokteran Respirasi. 1st ed. (Isbaniah F, ed.). Elsevier Singapore Pte Ltd; 2022.

Majdawati A. Uji Diagnostik Gambaan Lesi Foto Thorax pada Penderita dengan Klinis Tuberkulosis Paru. Mutiara Med. 2010;10(2):180-188.

Utami PR, Amelia N, Susanto V, Adfar TD. Pemeriksaan GeneXpert Terhadap Tingkat Positivitas Pemeriksaan Basil Tahan Asam (BTA) Metode Ziehl Neelsen Pada Penderita Suspek TB Paru. J Kesehat Perintis. 2021;8(1):82-90.

Chairani C, Utami PR, Indrayati S, Almurdi A, Rahmayana R. Perbedaan Hasil Pemeriksaan Mikroskopis BTA Pada Pasien TB Paru Sebelum dan Sesudah Pengobatan Fixed-Dose Combination (FDC) Fase Intensif. J Kesehat Perintis. 2023;10(1):68-73.

Zhu M, Han G, Takiff HE, et al. Times series analysis of age-specific tuberculosis at a rapid developing region in China, 2011-2016. Sci Rep. 2018;8(1):8727. doi:10.1038/s41598-018-27024-w

Andayani S. Prediksi Kejadian Penyakit Tuberkulosis Paru Berdasarkan Jenis Kelamin. J Keperawatan Muhammadiyah Bengkulu. 2020;8(2):135-140.

Hartiyah L, Rahmiati R, Dwi Santoyo D. Gambaran Hasil Pemeriksaan Tes Cepat Molekuler Mycobacterium Tuberculosis Di Rsud Ulin Banjarmasin Tahun 2020-2021. Homeostasis. 2023;6(1):69-76. doi:10.20527/ht.v6i1.8791

Sava C, Sava M, Drăgan A-M, et al. The Use of Xpert MTB/RIF Ultra Testing for Early Diagnosis of Tuberculosis: A Retrospective Study from a Single-Center Database. Genes (Basel). 2023;14(6). doi:10.3390/genes14061231

Kemenkes RI. Petunjuk Teknis Pemeriksaan TB Menggunakan Tes Cepat Molekuler.; 2017.

Tamtyas FI, Rini CS. The Detection of TB Lungs with Microscopic and the Rapid Molecular Test Methods. Medicra (Journal Med Lab Sci. 2020;3(1):1-4. doi:10.21070/medicra.v3i1.650

Wita A, Fransiska E. Hubungan Kv Terhadap Ketebalan Objek Ayu Wita Sari. J Heal. Published online 2018:17-21.

Lawn SD, Mwaba P, Bates M, et al. Advances in tuberculosis diagnostics: the Xpert MTB/RIF assay and future prospects for a point-of-care test. Lancet Infect Dis. 2013;13(4):349-361. doi:10.1016/S1473-3099(13)70008-2

Bomanji JB, Gupta N, Gulati P, Das CJ. Imaging in tuberculosis. Cold Spring Harb Perspect Med. 2015;5(6). doi:10.1101/cshperspect.a017814

Bhalla AS, Goyal A, Guleria R, Gupta AK. Chest tuberculosis: Radiological review and imaging recommendations. Indian J Radiol Imaging. 2015;25(3):213-225. doi:10.4103/0971-3026.161431

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Published

2024-08-03

How to Cite

Prisila, E., Sukirto, N. W., Umam Kurniawan, N., Rahayu, A. B., Yuniasih, D., Wira Oktaviana, A. ., Putri Nurulita, F. ., Sholikhah, A., & Awisarita, W. (2024). Utilization of Xpert MTB/RIF molecular test and Thorax Radiography as Tuberculosis Screening at PKU Muhammadiyah Bantul Hospital. Ahmad Dahlan Medical Journal, 5(1), 145–152. Retrieved from http://journal2.uad.ac.id/index.php/admj/article/view/10428

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