Factors Associated with Successful Tuberculosis Treatment in the Primary Health Care of Bekasi

Authors

  • Kartika Putri Amalia Faculty of Medicine, UPN Veteran Jakarta, Jakarta, Indonesia
  • Sri Rahayu Department of Pharmacy, UPN Veteran Jakarta, Jakarta, Indonesia
  • Erna Harfiani Department of Pharmacy, UPN Veteran Jakarta, Jakarta, Indonesia

DOI:

https://doi.org/10.26555/eshr.v4i2.5097

Keywords:

Medication adherence, Primary health care, Tuberculosis treatment, Bekasi

Abstract

Background: Tuberculosis is still a significant disease problem globally as it is one of ten causes of death worldwide and in Indonesia. Bekasi is the second-largest city with tuberculosis patients after Bandung, with 3,355 patients in 2015. The success rate of treatment that has not reached the standard in the primary health care of Bekasi, West Java, can be related to medication adherence, age, and nutritional status. Inadequate nutritional intake in tuberculosis patients will increase the recovery time. The more days of irregularity in taking the drug increases the likelihood of the patient having a default that can lead to drug-resistant tuberculosis. This study aimed to determine the correlation between anti-tuberculosis drug adherence, age, and nutritional status with tuberculosis treatment in new tuberculosis cases in the primary health care of Bekasi.

Method: This was analytic observational research with a cross-sectional design study in 311 new tuberculosis cases at 30 primary health care in Bekasi city period 2015. Data were analyzed using univariate data and then continued with the chi-square test and logistic regression test.

Results: The results of the univariate analysis were found to obtain patients' compliance by 84.9% adherent, productive age (91%), and nutritional status with IMT under 18.5 kg/m2 (68.8%). Chi-square test shown there was a significant relationship between medication adherence (p-value = 0.000; OR = 5917.5; 95%CI = 525.57 – 66626.6), age (p-value = 0.003; OR = 3.81; 95%CI = 1.63 – 8.90), and nutritional status (p-value = 0.000; OR = 7.88; 95%CI = 2.38 – 26.08) with therapeutic outcome. Logistic regression analysis showed that anti-tuberculosis drug adherence (p-value = 0.000; OR = 5917.5) was the most dominant variable related to tuberculosis treatment success.

Conclusion: We conclude that the success of tuberculosis treatment in the primary health care of the Bekasi period 2015 relates to anti-tuberculosis drug (medication) adherence, age, and nutritional status, while medication adherence has the most significant influence on the success of tuberculosis treatment.

References

Amaliah R. Factors associated with failure of conversion of patients with smear-positive pulmonary TB of the intensive phase treatment in the district of Bekasi in 2010. Universitas Indonesia; 2010.

WHO. Global Tuberculosis Report: Excecutive Summary 2020. Genewa; 2019. Available from: https://cdn.who.int/media/docs/default-source/hq-tuberculosis/global-tuberculosis-report-2020/execsumm_11nov2020.pdf?sfvrsn=be12e34e_9

Central Statistics Agency of West Java Province. West Java in Figures of Years 2015 (Profil Daerah Propinsi Jawa Barat Tahun 2015). Bandung; 2015.

Widiyanto A. The Relationship Between Compliance with Taking Medicines Healing of smear positive pulmonary TB patients at Puskesmas Delanggu Kabupaten Klaten. Integr J Heal Sci. 2016;6:35–40.

Aulia Y. Relationship of age, sex, and occupation with the success of tuberculosis treatment in patients who have received treatment in Sakti sub-district, Pidie, Aceh. Postgraduate Thesis Program, Syiah Kuala University. 2014. Available from: https://etd.unsyiah.ac.id/index.php?p=show_detail&id=4522

Fatimah, S, Intiyati, A, Mukhis, A AY. The Relationship of Nutritional Status By Curing Pulmonary TB Patients in Lung Poly at Sidoarjo Regional Hospital. 2012;60–74.

Darmanto D. Respirologi (Respirology Medicine). EGC. Jakarta; 2015.

Salsabela FE, Suryadinata H, Desy IF. Overview of Nutritional Status in Tuberculosis Patients at Hasan Sadikin General Hospital Bandung (Gambaran Status Nutrisi pada Pasien Tuberkulosis di Rumah Sakit Umum Pusat Hasan Sadikin Bandung). J Sist Kesehat. 2016;2(2):84–9.

Yuanasari. Evaluation of Anti Tuberculosis Drug Use and Compliance In Adult Patients with a Diagnosis of Pulmonary Tuberculosis at the Mantingan Ngawi Public Health Center for the Period of February-April 2009. Surakarta; Faculty of Pharmacy, Muhammadiyah University of Surakarta. Universitas Muhammadiyah Surakarta; 2009.

Kurniawan, N, HD, SR IG. Factors Affecting the Success of Pulmonary Tuberculosis Treatment. 2015;735–8.

Irianti T, Kuswandi, Yasin NM, Kusumanintyas RA. Mengenal Anti-Tuberkulosis. Grafika Indah. Yogyakarta: Grafika Indah; 2016. Available from: https://repository.ugm.ac.id/273526/1/Draft Buku Antituberkulosis 14 Desember.pdf

Kementerian Kesehatan. Pemerintah RI. Permenkes RI Nomor 67 tentang Penanggulangan Tuberkulosis. Indonesia Ministry of Health. Jakarta; 2016.

Ministry of Health RI. Indonesia Health Profile 2020. Jakarta: Balitbang Kemenkes RI. Jakarta; 2021.

Puspita E. Gambaran Status Gizi pada Pasien Tuberculosis Paru yang Menjalani Rawat Jalan di RSUD ARIFIN ACHMAD PEKANBARU. JOM FK. 2016;3(2):1–16.

Indonesia Ministry of Health. Tuberculosis Finds a Cure Until Healed. Indonesia Ministry of Health. Jakarta; 2015.

Salsabela, FE, Suryadinata, H AI. Overview of Nutritional Status in Tuberculosis Patients at Hasan Sadikin Central General Hospital. Padjajaran University. 2016.

Downloads

Published

2022-08-06

Issue

Section

Research Article