Risk Factors for Measles Infection During Measles Outbreaks in Southeast Asia: Literature Review

Authors

  • Pebriyani Dwi Rakhmawati Department of Public Health, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia
  • Safira Balqis Department of Public Health, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia
  • Hana Amada Nafisyah Department of Public Health, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia
  • Fidyatus Sholihah Department of Public Health, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia
  • Afni Andini Rikawati Department of Public Health, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia
  • Rosita Dwi Jayanti Department of Public Health, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia
  • Dwi Sarwani Sri Rejeki 1) Department of Public Health, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia; 2) Research Center for Rural Health, Institute for Research and Community Services, Jenderal Soedirman University, Indonesia https://orcid.org/0000-0003-0180-4572

DOI:

https://doi.org/10.26555/eshr.v8i1.14891

Keywords:

Outbreak, Measles, Risk Factors, Southeast Asia

Abstract

Background: Measles remains a major health problem in Southeast Asia due to high transmission rates. In 2025, Indonesia ranked seventh with 5,035 cases, while the 2020-2025 trend shows significant fluctuations in Indonesia, the Philippines, and Laos due to outbreaks during certain periods. This study aims to identify risk factors for measles infection during outbreaks in Southeast Asia through a literature review.

Method: The literature review was conducted using databases of PubMed, ProQuest, ScienceDirect, and Google Scholar with measles related keywords. Full-text, open-access articles published within the last 10 years and originating from Southeast Asia were included. Of the 21,051 articles identified and seven articles met PRISMA criteria. Data were extracted, assessed using JBI checklist, and synthesized to identify measles risk factors.

Results: The results showed that risk factors for measles during outbreaks included individual factors (young age, malnutrition, incomplete immunization, history of contact), health services (limited access, delayed treatment), environment (housing density), and socio-demographics (negative perceptions of immunization, indigenous peoples).

Conclusion: Therefore, by identifying these risk factors, measles outbreak control in Southeast Asia can be focused on immunization, nutrition, health services, and community education.

References

Agushybana F, Nuryanto, Margawati A. Buku Pintar Imunisasi Campak dan Rubella. Jati SP, Martini, editors. FKM UNDIP Press. 2018.

Halim RG. Campak Pada Anak. Vol. 43, Cermin Dunia Kedokteran. 2016. https://doi.org/10.55175/cdk.v43i3.31

WHO. Measles and Rubella Global Update on September 2025. 2024.

WHO. Immunization Agenda 2030: A Global Strategy to Leave No One Behind. 2020.

Nassar AAH, Al Amad MA, Qasim M, Dureab F. Risk Factors for Measles Outbreak in Ataq and Habban Districts, Shabwah Governorate, Yemen, February to May 2018. BMC Infect Dis. 2021;21(1):1. https://doi.org/10.1186/s12879-021-06207-3

Tariku MK, Worede DT, Belete AH, Bante SA, Misikir SW. Attack Rate, Case Fatality Rate and Determinants of Measles Infection During a Measles Outbreak in Ethiopia: Systematic Review and Meta-analysis. BMC Infect Dis. 2023 Dec 1;23(1). https://doi.org/10.1186/s12879-023-08757-0

Domai FM, Agrupis KA, Han SM, Sayo AR, Ramirez JS, Nepomuceno R, et al. Measles outbreak in the Philippines: epidemiological and clinical characteristics of hospitalized children, 2016-2019. Lancet Reg Health West Pac [Internet]. 2022;19:100334. Available from: https://doi.org/10.1016/j.

Tran MD, Pham NTH, Vu HN, Tran MH, Ngo HA, Phan PH. Risk Factors for Severe Complications and Mortality Among Hospitalized Children with Measles During a Major Outbreak in Northern Vietnam, 2017 - 2019. 2023 Oct 16; Available from: http://medrxiv.org/lookup/doi/10.1101/2023.07.16.23292745

Rosha PT. Investigation of Mixed Outbreak (measles-rubella) in Rural Community Temanggung, Central Java. HIGEIA (Journal of Public Health Research and Development). 2024 Apr 2;8(2):165–76. https://doi.org/10.15294/higeia.v8i2.78239

Sitepu FY, Depari E, Mudatsir M, Harapan H. Being Unvaccinated and Contact with Measles Cases as The Risk Factors of Measles Outbreak, North Sumatera, Indonesia. Clin Epidemiol Glob Health. 2020;8:239–43. https://doi.org/10.1016/j.cegh.2019.08.006

Yurnila, Martha E. Immunization Status and Risk of Measles/Rubella Incidence During Outbreak. Jurnal Kesehatan [Internet]. 2024;15(1):41–7. Available from: http://ejurnal.stikesprimanusantara.ac.id/

Raodah, Armiatin, Husna A, Putri RT. Faktor-faktor yang Berhubungan Kejadian Campak Pada Balita di Wilayah Kerja Puskesmas Celala Tahun 2024. Jurnal Kesehatan Saelmakers Perdana. 2024;7(2). https://doi.org/10.35730/jk.v15i1.1055

Ardhiansyah F, Budi KR, Suwondo A, Setiawati M, Kartini A. Faktor Risiko Campak Anak Sekolah Dasar pada Kejadian Luar Biasa di Kabupaten Pesawaran, Provinsi Lampung. Jurnal Epidemiologi Kesehatan Komunitas. 2019;2(4). https://doi.org/10.14710/jekk.v4i2.4798

Portnoy A, Jit M, Helleringer S, Verguet S. Impact of Measles Supplementary Immunization Activities on Reaching Children Missed by Routine Programs. Vaccine. 2018 Jan 2;36(1):170–8. https://doi.org/10.1016/j.vaccine.2017.10.080

Durrheim DN, Baker MG, Capeding MR, Goh KT, Lee D, Papania M, et al. Accelerating Measles Elimination in the Western Pacific Region During the Calm Between the Storms. Lancet Reg Health West Pac [Internet]. 2022;23:100495. https://doi.org/10.1016/j

Xavier G, Asikin Mohd Azmi N, Sakinah Syed Ismail S, Sandran G, Thinakaran IK, Mustafa Mohamed Hir H, et al. A Report On Imported Measles Outbreak in A Factory At Manjung District, Malaysia In 2019. Malaysian Journal of Public Health Medicine. 2024;24(2):12–25. https://www.mjphm.org/index.php/mjphm/article/view/2166

Afdhalash BJ, Adriyani R. Korelasi Kondisi Fisik Rumah dan Karakteristik Balita Dengan Kasus Campak di Kota Surabaya. The Indonesian Journal Public Health. 2019;14(1):37–49. https://doi.org/10.20473/ijph.v14i1.2019.37-49

Dias Susanti R, Ady Nugroho T, Martalena Y. Faktor-faktor Yang Berhubungan Dengan Kejadian Luar Biasa Campak di UPTD Puskesmas Kedondong Kabupaten Pesawaran Tahun 2023. Sains Medisina. 2025;3(4). https://doi.org/10.63004/snsmed.v3i4.724

Hendrik Sahat Marasi J, Mahanani D, Haanim Lathifah A, Aulia Haryanti A, Elysia Fatiha D, Fuadi Rica Susanti I, et al. Gambaran Kesehatan Lingkungan Terhadap Pencegahan Penyakit Campak Pada Balita di Jakarta Selatan Tahun 2024. Integrative Perspectives of Social and Science Journal (IPSSJ). 2025;2(3):4038. https://ipssj.com/index.php/ojs/article/view/527

Armiatin. Faktor-faktor yang Berhubungan Dengan Kejadian Campak di Puskesmas Kota Juang Kabupaten Bireuen Tahun 2022. Jurnal Cakrawala Ilmiah. 2023;2(7). https://doi.org/10.53625/jcijurnalcakrawalailmiah.v2i7.5285

Downloads

Published

2026-02-08

Issue

Section

Articles