Epidemiological Characteristics and Temporal Trends of Dengue Fever in the Mlati 2 Primary Health Care, Sleman, Indonesia, 2021–2024
DOI:
https://doi.org/10.26555/eshr.v8i2.15880Keywords:
Aedes aegypti, Dengue hemorrhagic fever, Epidemiology, Outbreak surveillance.Abstract
Background: Dengue is a mosquito-borne viral disease transmitted mainly by Aedes aegypti and Aedes albopictus. A rapid increase in cases may indicate a potential outbreak and requires timely surveillance. This study aimed to describe dengue cases by person, place, and time in the Mlati 2 Public Health Center area from 2021 to 2024 and identify potential outbreak patterns.
Method: This quantitative descriptive study used secondary data from epidemiological investigation records at Mlati 2 PHC. “Dengue cases” included all cases classified as DF, DHF, DSS, and DD. A total of 82 cases recorded from 2021 to 2024 were included. Data were analyzed descriptively and presented by person, place, time, laboratory diagnosis, and House Larvae-Free Index.
Results: Most cases occurred among adults aged 19–59 years, with more females than males. Sumberadi Village recorded the highest number of cases, followed by Tlogoadi and Tirtoadi. DHF was the most frequent classification, while cases in 2024 showed more varied diagnoses, including DF, DHF, DD, and DSS. The three-year minimum–maximum pattern showed that cases in February, March, April, May, and August 2024 exceeded the historical maximum from 2021 to 2023, indicating potential outbreak signals. The House Larvae-Free Index remained below the national standard of 95% during the study period.
Conclusion: Dengue cases occurred annually in the Mlati 2 Public Health Center area, with a marked increase in 2024. Cases were mainly found among productive-age adults and concentrated in Sumberadi Village. The potential outbreak signals and low House Larvae-Free Index highlight the need to strengthen surveillance, timely reporting, epidemiological investigation, and community-based vector control.
References
World Health Organization. Dengue and Severe Dengue. 2024.
Kemenkes RI. Profil Kesehatan Indonesia 2023. 2024.
Dinas Kesehatan Provinsi Yogyakarta. Profil Kesehatan Provinsi Yogyakarta Tahun 2022. Yogyakarta: Dinas Kesehatan Yogyakarta; 2022.
Putri AEL, Subhi M, Syafitri DP. Gambaran Kasus Demam Berdarah Dengue Puskesmas X Kota Malang Tahun 2019-2022. Media Husada J Environ Heal Sci. 2023;3(1):12–8.
Kementerian Kesehatan RI. PMK No. 1501 Tahun 2010 tentang Jenis Penyakit Menular Tertent Yang Menimbulkan Wabah. 2010.
Komaling D, Sumampouw OJ, Sondakh RC. Determinan Kejadian Demam Berdarah Dengue di Kabupaten Minahasa Selatan Tahun 2016-2018. J Public Heal Community Med. 2020;1(1):57–64.
Puskesmas Mlati 2 Sleman. Sehat Bersama Puskesmas Mlati 2 Sleman. 2024.
Zebua R, Gulo VE, Purba I, Gulo MJK. Perubahan Epidemiologi Demam Berdarah Dengue (DBD) di Indonesia Tahun 2017-2021. SEHATMAS J Ilm Kesehat Masy. 2023;2(1):129–36.
Avidsyah MA, Asrina A, Idris FP. Hubungan Usia Dan Kepadatan Hunian Dengan Kejadian Pasien Demam Berdarah Dengue Di Wilayah Kerja Puskesmas Tamalanrea Kota Makassar. Wind Public Heal J. 2023;5(2):321–30.
Ernyasih, Zulfa R, Andriyani, Fauziah M. Analisis Spasial Kejadian Demam Berdarah Dengue Di Kota Tangerang Selatan Tahun 2016-2019. An-Nur J Kaji dan Pengemb Kesehat Masy. 2020;1(1):74–98.
Mahendra YI, Syaniah AE, Astari R, Sy TZM, Aulia W. Analisis Penyebab Demam Berdarah Dengue (DBD) Desa Bandar Klippa Kecamatan Percut Sei Tuan. J Ilm Univ Batanghari Jambi. 2022;22(3):1732.
Manrique-Saide P, Herrera-Bojórquez J, Villegas-Chim J, Puerta-Guardo H, Ayora-Talavera G, Parra-Cardeña M, et al. Protective effect of house screening against indoor Aedes aegypti in Mérida, Mexico: A cluster randomised controlled trial. Trop Med Int Health. 2021 Dec;26(12):1677–88.
Montenegro-Quiñonez CA, Louis VR, Horstick O, Velayudhan R, Dambach P, Runge-Ranzinger S. Interventions against Aedes/dengue at the household level: a systematic review and meta-analysis. EBioMedicine. 2023 Jul;93:104660.
Facchinelli L, Alsharif B, Jones JD, Matope A, Barbosa RMR, Ayres CFJ, et al. Mapping Aedes aegypti indoor resting behavior reveals a preference vulnerable to householder-led vector control. PNAS Nexus. 2023 Jul 1;2(7):pgad226. Available from: https://doi.org/10.1093/pnasnexus/pgad226
Kementerian Kesehatan. Cara Mencegah DBD dengan Menjaga Lingkungan dan Diri Sendiri. Kementerian Kesehatan. 2024.
David MR, Maciel-de-Freitas R, Petersen MT, Bray D, Hawkes FM, Fernández-Grandon GM, et al. Aedes aegypti oviposition-sites choice under semi-field conditions. Med Vet Entomol. 2023 Dec;37(4):683–92.
Baitanu JZ, Masihin L, Rustan LD, Siregar D, Aiba S. Hubungan Antara Usia, Jenis Kelamin, Mobilitas, Dan Pengetahuan Dengan Kejadian Demam Berdarah Dengue Di Wulauan, Kabupaten Minahasa. Malahayati Nurs J. 2022;4(5):1230–41.
Pinem S br, Rahimi A, Chiuman L. Gambaran Klinis Dengue Hemorrhagic Fever (DHF) Atau Demam Berdarah Dengue pada Usia Dewasa di Rumah Sakit Umum Royal Prima Medan pada Januari – Desember. J Pendidik dan Konseling. 2022;4(6):6152–8.
Aliyyu H, Riani SN, Ferlianti R. Gambaran Kasus Demam Berdarah Dengue Pada Usia Anak Sekolah Di Rsud Dr. Drajat Prawiranegara Tahun. J Locus Penelit dan Pengabdi. 2023;2(10):978–86.
Alvarado-Castro VM, Vargas-De-León C, Paredes-Solis S, Li-Martin A, Nava-Aguilera E, Morales-Pérez A, et al. The influence of gender and temephos exposure on community participation in dengue prevention: a compartmental mathematical model. BMC Infect Dis. 2024;24(1):463. Available from: https://doi.org/10.1186/s12879-024-09341-w
Watts MJ, Kotsila P, Mortyn PG, Sarto I Monteys V, Urzi Brancati C. Influence of socio-economic, demographic and climate factors on the regional distribution of dengue in the United States and Mexico. Int J Health Geogr. 2020 Nov;19(1):44.
Sajib AH, Akter S, Saha G, Hossain Z. Demographic-environmental effect on dengue outbreaks in 11 countries. PLoS One. 2024 Sep 11;19(9):e0305854. Available from: https://doi.org/10.1371/journal.pone.0305854
Tian N, Zheng JX, Guo ZY, Li LH, Xia S, Lv S, et al. Dengue Incidence Trends and Its Burden in Major Endemic Regions from 1990 to 2019. Trop Med Infect Dis. 2022 Aug;7(8).
Ahmad ZF, Salsabila Mongilong N, Kadir L, Indah Nurdin SS, Rahmawaty Moo D. Perbandingan Manifestasi Klinis Penderita Demam Berdarah. Indones J Pharm Educ. 2023;3(1):143 – 154.
Sumampouw OJ. Epidemiologi Demam Berdarah Dengue di Kabupaten Minahasa Sulawesi Utara. Sam Ratulangi J Public Heal. 2020;1(1):001.
Kaheming EN, Mantjoro EM, Kalesaran AFC. Analisis Spasial Kejadian Demam Berdarah Dengue (DBD) Di Wilayah Kerja Puskesmas Talawaan Tahun 2020-2022. J Kesehat Tambusai. 2020;4(3):2896–904.
Kulsum U, Sutrisno S, Purwanto E, Norma N. Faktor Resiko Demam Berdarah Dengue (Dbd) Dengan Kejadian Dbd Di Wilayah Kerja Puskesmas Bunyu Kabupaten Bulungan. SAINTEKES J Sains, Teknol Dan Kesehat. 2023;2(3):456–69.
Ashary R, Ferlianti R, Riani SN. Gambaran Kasus Demam Berdarah Dengue (DBD) Berdasarkan Jenis Kelamin Anak di RSUD Dr. Drajat Prawiranegara Serang pada Tahun 2021. Jr Med J. 2024;2(6):715–22.
Taufik A, Hasibuan PA, Putri FD, Wulandari A, Mutika WT, Lisa M, et al. Jurnal Kesmas Untika Luwuk : Public Health Journal Case Series : Angka Kematian Demam Berdarah Dengue Berdasarkan. urnal Kesmas Untika LuwukPublic Heal J. 2024;15(2):125–33.
Syahbani AN, Sukendra DM. Peramalan Jumlah Kasus Demam Berdarah Dengue Berdasarkan Surveilans Kasus dan Curah Hujan. HIGEIA J Public Heal Res Dev. 2020;4(2):1–13.
Marisa YT, Ahmad A. Dengue Syok Syndrome. Hum Care J. 2024;9(1):115–25.
Kementerian Kesehatan. Gejala Demam Berdarah yang Perlu Diwaspadai. Kementerian Kesehatan. 2023.
Adinata IMAV, Rahmawati F, Waskito BA. Pengaruh Dengue Hemorrhagic Fever Derajat 3 Dan 4 Terhadap Kehamilan Trimester 3 (36 Minggu). Calvaria Med J. 2023;1(1):37–42.
Undang-undang Republik Indonesia. Undang-Undang Republik Indonesia Nomor 44 Tahun 2009 Tentang Rumah Sakit. 2009. 1–24 p.
Surya R, Abdussalaam F, Suryani AI. Sistem Informasi Pelaporan Kdrs Demam Berdarah Di Rsud Bandung Kiwari. JIRK J Innov Res Knowl. 2024;4(4):2035–44.
Centers for Disease Control and Prevention. What is Case Surveillance? Centers for Disease Control and Prevention. 2025.
Sutriyawan A, Suherdin S. Studi Mixed Method: Gambaran Epidemiologi dan Analisis Sistem Surveilans Demam Berdarah Dengue (DBD) Di Kota Bandung. Indones J Infect Dis. 2022;8(2):15–29.
Ernawati, Fajrianti G, Yandra B. Analisis Faktor Lingkungan Fisik Dan Perilaku Terhadap Kejadian Demam Berdarah Dengue. J Penelit Perawat Prof. 2024;6(6):2987–96.
Kementerian Kesehatan. Penyelidikan dan Penanggulangan Kejadian Luar Biasa Penyakit Menular dan Keracunan Pangan. Jakarta: Kementerian Kesehatan; 2020.
Putra IND, Anggara A, Sabir M. Pengetahuan dan Sikap Orang Tua terhadap Kejadian Penyakit Demam Berdarah Dengue (DBD) Anak Di Puskesmas Kamonji Kota Palu. J Med Prof. 2021;3(3):240–9.
Surja SS, Rimbo ST, Putra A, Eclesia S, Mario RA, Akris DL V, et al. Edukasi Masyarakat Melalui Instagram: Nyamuk Ber Wobachia Untuk Pencegahan Dengue. Mitramas J Pengabdi dan Pemberdaya Masy. 2024;2(2):104–13.
Saraswati U, Supriyati E, Rahayu A, Rovik A, Kurniasari I. Kajian aspek keamanan nyamuk Aedes aegypti Linnaeus ber- Wolbachia di Yogyakarta , Indonesia. J Entomol Indones. 2023;20(2):117–28.
Fox T, Sguassero Y, Chaplin M, Rose W, Doum D, Arevalo-Rodriguez I, et al. Wolbachia‐carrying Aedes mosquitoes for preventing dengue infection. Vol. 2023, The Cochrane Database of Systematic Reviews. 2023.
Edenborough K, Supriyati E, Dufault S, Arguni E, Indriani C, Denton J, et al. Dengue virus genomic surveillance in the applying Wolbachia to eliminate dengue trial reveals genotypic efficacy and disruption of focal transmission. Sci Rep. 2024;14(1):28004. Available from: https://doi.org/10.1038/s41598-024-78008-y
Lim JT, Mailepessov D, Chong CS, Dickens B, Lai YL, Ng Y, et al. Adjacent spillover efficacy of Wolbachia for control of dengue: emulation of a cluster randomised target trial. BMC Med. 2025;23(1):184. Available from: https://doi.org/10.1186/s12916-025-03941-2
Abbas S, Abbas M, Alam A, Hussain N, Irshad M, Khaliq M, et al. Mitigating dengue incidence through advanced Aedes larval surveillance and control: A successful experience from Pakistan. Bull Entomol Res. 2024/05/21. 2024;114(3):444–53. Available from: https://www.cambridge.org/core/product/2DDBF6AA764D6BF590DA21014C3D668F
Samsudin NA, Othman H, Siau CS, Zaini Z ’Izzat I. Exploring community needs in combating aedes mosquitoes and dengue fever: a study with urban community in the recurrent hotspot area. BMC Public Health. 2024 Jun;24(1):1651.
Khan J, Adil M, Tsheten T, Manrique-Saide P, Zhang D, Aziz A, et al. Assessing Aedes mosquito larval indicators, dengue virus infection rates, and risk factors in Khyber Pakhtunkhwa: Insights for improved vector control strategies. PLoS Negl Trop Dis. 2025 Jul 22;19(7):e0013252. Available from: https://doi.org/10.1371/journal.pntd.0013252
Sahavechaphan N, Chatrattikorn A, Rattananen M, Sadakorn P, Areechokchai D, Iamsirithaworn S. Identifying villages and breeding habitats for dengue transmission in Thailand: insights from long-term larval surveys. BMC Infect Dis. 2024;24(1):523. Available from: https://doi.org/10.1186/s12879-024-09398-7
Djaja B, Prianto Y, Ridwan FH, Karyadika IMH. Implementation of Policy Regulation on Dengue Fever Treatment Through Gene Drive of Wolbachia Bacteria. J Law, Polit Humanit. 2024;5(1):169–78.
Sugianto MA. Strategi Pencegahan dan Pengendalian DBD (Kasus di Kecamatan Kuta Utara Kabupaten Badung). Bappenas Work Pap. 2023;6(1):141–54.
Kementerian Kesehatan. Peraturan Menteri Kesehatan Nomor 82 Tahun 2014 tentang Pencegahan dan Pengendalian Penyakit Menular. 2014. 1–20 p.
Zahro RA, Maulana J, Lu’lu Fitriyani N. Literatur Review: Hubungan Kejadian Demam Berdarah Dengue (DBD) Berdasarkan Kepadatan Penduduk dan Angka Bebas Jentik (ABJ). J Glob Multidiscip. 2023;1(6):798–808.
Aung SH, Mon Kyaw AM, Jittamala P, Lawpoolsri S, Soonthornworasiri N, Sriwichai P, et al. Efficacy of household Aedes larval control practices in a peri-urban township, Yangon, Myanmar: Implication for entomological surveillance. Heliyon. 2023;9(7):e18083. Available from: https://www.sciencedirect.com/science/article/pii/S240584402305291X
Cavalcante ACP, de Olinda RA, Gomes A, Traxler J, Smith M, Santos S. Spatial modelling of the infestation indices of Aedes aegypti: an innovative strategy for vector control actions in developing countries. Parasit Vectors. 2020 Apr;13(1):197.
Dinas Kesehatan Sleman. Profil Kesehatan Kabupaten Sleman Tahun 2024. Yogyakarta: Dinas Kesehatan Sleman; 2024.
Adi U, Citra I, A. AR, Warsito T, Eggi A, Ridwan AM, et al. Efficacy of Wolbachia-Infected Mosquito Deployments for the Control of Dengue. N Engl J Med. 2021 Jun 9;384(23):2177–86. Available from: https://doi.org/10.1056/NEJMoa2030243
Martiningsih I, Trisnowati H, Sulistyawati S. Effectiveness of Health Promotion Strategies on Dengue Hemorrhagic Fever Prevention and Control : A Literature Review. Heal Tadulako J (Jurnal Kesehat Tadulako). 2025;11(4):601–10.
Downloads
Published
Issue
Section
License
Copyright (c) 2026 Retno Widyaningrum, Liena Sofiana, Rokhmayanti Rokhmayanti, Desi Nurfita, Ardyawati Wira Oktaviana

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
Authors who publish with ESHR agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License (CC BY-SA 4.0) that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.






