Bibliometric Analysis of Gene Research on Aging
DOI:
https://doi.org/10.12928/admj.v5i2.11996Keywords:
Bibliometric, Gene, Age, Research, agingAbstract
Aging is associated with various factors identified in the hallmark of aging. Numerous studies have been conducted to identify genes involved in the aging process, allowing for a comprehensive understanding of this phenomenon. This study aims to provide an overview of research on genes associated with the aging process. Data for this study was obtained and analyzed from the SCOPUS database covering the period from 2014 to 2024, with a focus on medicine, neuroscience, and nursing. The keywords used for the search were "gene," "longevity," and "aging." The search results were filtered to match the study's purpose and were limited to articles in English. The data obtained was analyzed using VOSviewer version 1.6.20. A total of 1,603 articles were analyzed. The highest number of publications occurred in 2021. The most frequent sources for these articles were the journals Biogerontology and The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. The United States was the leading contributor in publications (n=488), with Harvard Medical School producing the highest number (n=45). The most-cited article was by Loboda in 2016 (1,863 citations). Research on genes associated with aging has shifted from identifying genes (2017-2019) to focusing on the functions of these genes in physiological processes and other risk factors of aging. In conclusion, the aging research has evolved from focusing solely on gene identification to exploring the physiological functions and risk factors related to aging.
References
Blankenburg H, Pramstaller PP, Domingues FS. A network-based meta-analysis for characterizing the genetic landscape of human aging. Biogerontology. 2018;19(1):81-94. doi:10.1007/s10522-017-9741-5
chen R, Morris BJ, Donlon TA, et al. FOXO3 longevity genotype mitigates the increased mortality risk in men with a cardiometabolic disease. Aging. 2020;12(23):23509-23524. www.aging-us.com
Donlon TA, Morris BJ, Chen R, et al. FOXO3 longevity interactome on chromosome 6. Aging Cell. 2017;16(5):1016-1025. doi:10.1111/acel.12625
Kilic U, Gok O, Erenberk U, et al. A remarkable age-related increase in SIRT1 protein expression against oxidative stress in elderly: SIRT1 gene variants and longevity in human. PLoS One. 2015;10(3). doi:10.1371/journal.pone.0117954
Cattaneo M, Aleksova A, Malovini A, et al. BPIFB4 and its longevity-associated haplotype protect from cardiac ischemia in humans and mice. Cell Death Dis. 2023;14(8). doi:10.1038/s41419-023-06011-8
Hepowit NL, Blalock E, Lee S, Bretland KM, MacGurn JA, Dickson RC. Reduced sphingolipid biosynthesis modulates proteostasis networks to enhance longevity. Aging. 2023;15(2):472-491. doi:10.18632/aging.204485
Gola F, Gaiaschi L, Roda E, et al. Voghera Sweet Pepper: A Potential Ally against Oxidative Stress and Aging. Int J Mol Sci. 2023;24(4). doi:10.3390/ijms24043782
Yerges-Armstrong LM, Chai S, O’Connell JR, et al. Gene Expression Differences between Offspring of Long-Lived Individuals and Controls in Candidate Longevity Regions: Evidence for PAPSS2 as a Longevity Gene. Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 2016;71(10):1295-1299. doi:10.1093/gerona/glv212
Pereira Da Silva A, Costa MDC, Aguiar L, et al. Impact on Longevity of Genetic Cardiovascular Risk and Lifestyle including Red Meat Consumption. Oxid Med Cell Longev. 2020;2020. doi:10.1155/2020/1305413
Taka C, Hayashi R, Shimokawa K, et al. SIRT1 and FOXO1 mRNA expression in PBMC correlates to physical activity in COPD patients. International Journal of COPD. 2017;12:3237-3244. doi:10.2147/COPD.S144969
Curjuric I, Imboden M, Bridevaux PO, et al. Common SIRT1 variants modify the effect of abdominal adipose tissue on aging-related lung function decline. Age (Omaha). 2016;38(3). doi:10.1007/s11357-016-9917-y
Sadria M, Layton AT. Interactions among mTORC, AMPK and SIRT: a computational model for cell energy balance and metabolism. Cell Communication and Signaling. 2021;19(1). doi:10.1186/s12964-021-00706-1
Lilja S, Stoll C, Krammer U, et al. Five days periodic fasting elevates levels of longevity related christensenella and sirtuin expression in humans. Int J Mol Sci. 2021;22(5):1-15. doi:10.3390/ijms22052331
Zhao Y, Wu L, Yue X, et al. A polymorphism in the tumor suppressor p53 affects aging and longevity in mouse models. Published online 2018. doi:10.7554/eLife.34701.001
Dato S, Soerensen M, De Rango F, et al. The genetic component of human longevity: New insights from the analysis of pathway-based SNP-SNP interactions. Aging Cell. 2018;17(3). doi:10.1111/acel.12755
Age-dependent expression changes of circadian system-related genes reveal a potentially conserved link to aging.
Rangaraju S, Levey DF, Nho K, et al. Mood, stress and longevity: Convergence on ANK3. Mol Psychiatry. 2016;21(8):1037-1049. doi:10.1038/mp.2016.65
Longo VD, Di Tano M, Mattson MP, Guidi N. Intermittent and periodic fasting, longevity and disease. Nat Aging. 2021;1(1):47-59. doi:10.1038/s43587-020-00013-3
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