The Relationship Between Oral Antidiabetic Treatment And Blood Sugar Level Among Type 2 Diabetes Mellitus Patients in Nur Hidayah Hospital Yogyakarta.
DOI:
https://doi.org/10.12928/dpphj.v19i1.11948Keywords:
Blood sugar levels, Diabetes mellitus, Oral antidiabetic, Outcome therapyAbstract
Background: Diabetes mellitus is a chronic disease that poses a global health threat, with type 2 diabetes mellitus accounts for 90% of all cases. In Indonesia, diabetes mellitus is among the causes of high mortality due to non-communicable diseases. If not treated properly, type 2 diabetes mellitus can lead to various complications, potentially worsening the patient's condition. To address this, blood glucose levels must be controlled through the use of oral antidiabetic medications, either as monotherapy or in combination therapy. This study aims to the accuracy of oral antidiabetic drugs use and its therapy outcomes (blood sugar levels) in type 2 diabetes mellitus patients at Nur Hidayah Hospital Yogyakarta. Method: This study is an observational study with retrospective data collection, carried out using the purposive sampling method. A total of 75 samples were obtained from 298 populations that met the specified criteria. Univariate data analysis methods are presented in the form of percentages and tables, including analyses of patient characteristics, treatment characteristics, and therapy outcomes. Subsequently, bivariate analysis was conducted using the chi-square test to determine the relationship between the accuracy of oral antidiabetic drugs use and therapy outcomes, specifically blood sugar levels of patients with type 2 diabetes mellitus. Results: The findings of the analysis performed using the chi-square test revealed a correlation between the accuracy of oral antidiabetic medication and blood sugar levels in patients (p-value=0.012). Conclusion: proper use of oral antidiabetics shows that the patient's blood sugar levels are controlled.
References
American Diabetes Association Professional Practice Committee. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes—2022. Diabetes Care. 2021;45:S17–38. https://doi.org/10.2337/dc22-S002.
Galicia-Garcia U, Benito-Vicente A, Jebari S, Larrea-Sebal A, Siddiqi H, Uribe KB, et al. Pathophysiology of Type 2 Diabetes Mellitus. Int J Mol Sci. 2020; 21:6275. https://doi.org/10.3390/ijms21176275.
WHO. Guidelines for the prevention, management and care of diabetes mellitus. Cairo: 2006.
Indonesian Ministry of Health. Laporan Nasional Riskesdas 2018. Jakarta: 2019.
Kazi A, Blonde L. Classification of diabetes mellitus. Clin Lab Med 2001;21:1–13.
Begic E, Arnautovic A, Masic I. Assessment of Risk Factors for Diabetes Mellitus Type 2. Mater Sociomed. 2016; 28:187–90. https://doi.org/10.5455/MSM.2016.28.187-190.
Lestari MP, Faridah IN, Maliza R, Dania H, Widianingrum M, Perwitasari DA. Identification of SNP rs1799854 ABCC8 gene and blood glucose levels in patients with type 2 diabetes mellitus at Moewardi hospital Surakarta Solo. Pharmaciana. 2021; 11:338–46. https://doi.org/10.12928/PHARMACIANA.V11I3.19100.
Sulastri, Perwitasar DA, Supadmi W. Analisis Efektivitas Biaya Penggunaan Metformin dan Metformin-Glimepirid pada Pasien Diabetes Melitus Tipe 2 di Dua Puskesmas Kulon Progo Yogyakarta: Mellitus Patients at the Two Public Health Centers Kulon Progo Yogyakarta Cost-Effectiveness Analysis of. Indones J Pharm Nat Prod. 2023; 6:143–53. https://doi.org/10.35473/IJPNP.V6I02.2306.
Linden S, Erwina W. Terapi Penggunaan Obat Antidiabetik Oral pada Pasien Diabetes Melitus Tipe 2 Rawat Jalan di Rumah Sakit Swasta Samarinda. J Pharm Sci. 2022; 5:214–26. https://doi.org/10.36490/JOURNAL-JPS.COM.V5I2.127.
Sylvia Puspita, Kuncara Nata Waskita, Vivi Rosalina. Efektivitas Antidiabetik Oral Baik Kombinasi Maupun Tunggal Pada Pasien Diabetes Mellitus Tipe Ii Di Rsud Caruban. J Sains Dan Kesehat. 2023;5:57–66. https://doi.org/10.57214/jusika.v5i2.293.
Chien HH, Chang CT, Chu NF, Hsieh SH, Huang YY, Lee I Te, et al. Effect of glyburide-metformin combination tablet in patients with type 2 diabetes. J Chin Med Assoc. 2007;70:473–80. https://doi.org/10.1016/S1726-4901(08)70044-3.
Pebriarti IW, Anggitasari W, Mayasari S, Darrojah UN, Pramesti LA. Ketepatan Penggunaan Obat Oral Antidiabetik pada Pasien Diabetes Melitus Tipe 2 di Instalasi Rawat Inap. MPI (Media Pharm Indones). 2024;6:83–91. https://doi.org/10.24123/MPI.V6I1.6386.
Mayasari S, Anggitasari W, Pebriarti IW. Drug rationality profile in diabetes mellitus patients. J Eduhealth. 2023;14:175–81.
Jha PK, Shukla H, Makwana A, Kakkad A. Pharmacotherapy of Type 2 Diabetes Mellitus. In: Chlup R, editor. Type 2 Diabetes 2024 - From Early Suspicion to Eff. Manag., IntechOpen. 2023. https://doi.org/10.5772/INTECHOPEN.1002309.
Apristina A, Nurinda E, Kusumawardani N, Yugistyowati A, Dwinta E. Analisis Hubungan Tingkat Kepatuhan Penggunaan Obat terhadap Luaran Klinis Pasien PROLANIS Program Rujuk Balik Diabetes dengan Hipertensi di Puskesmas Minggir pada Masa Pandemi COVID-19. Pharm J Indones. 2023;8:149–56. https://doi.org/10.21776/UB.PJI.2023.008.02.6.
Bidulka P, Lugo-Palacios DG, Carroll O, O’Neill S, Adler AI, Basu A, et al. Comparative effectiveness of second line oral antidiabetic treatments among people with type 2 diabetes mellitus: emulation of a target trial using routinely collected health data. BMJ. 2024; 385:e077097. https://doi.org/10.1136/BMJ-2023-077097.
Sangruangake M, Srisuwan P, Ruangsuksud P, Solikhah S, Sungworawongpana T. The Factor of Association of Diabetes Knowledge in Diabetes Mellitus type 2 patients. Dis Prev Public Heal J. 2022;16:70–8. https://doi.org/10.12928/DPPHJ.V16I1.5293.
Fitriani F, Barus T. Perbandingan Efektifitas antara Glimepirid dan Glikuidon untuk Menurunkan Glukosa Darah pada Pasien Diabets Melitus Tipe 2 di Rumah Sakit “X” Tahun 2018. Soc Clin Pharm Indones Journal. 2019. Vol 2019;4:24–9.
Lee YM, Lin PR, Sia HK. Oral antidiabetic therapy versus early insulinization on glycemic control in newly diagnosed type 2 diabetes patients: a retrospective matched cohort study. Sci Rep. 2024;14. https://doi.org/10.1038/S41598-024-66468-1.
Ramdini DA, Wahidah LK, Atika D. Evaluasi Rasionalitas Penggunaan Obat Diabetes Melitus Tipe II pada Pasien Rawat Jalan di Puskesmas Pasir Sakti Tahun 2019. J Farm Lampung. 2020;9:67–76. https://doi.org/10.37090/JFL.V9I1.334.
Yazdkhasti M, Jafarabady K, Shafiee A, Omran SP, Mahmoodi Z, Esmaeilzadeh S, et al. The association between age of menopause and type 2 diabetes: a systematic review and meta-analysis. Nutr Metab (Lond). 2024;21:87. https://doi.org/10.1186/S12986-024-00858-0.
Indonesian Ministry of Health. Hari Diabetes Sedunia Tahun 2018 - Penyakit Tidak Menular Indonesia 2018. https://p2ptm.kemkes.go.id/tag/hari-diabetes-sedunia-tahun-2018 (accessed March 18, 2025).
Xing Z, Kirby RS, Alman AC. Association of age at menopause with type 2 diabetes mellitus in postmenopausal women in the United States: National Health and Nutrition Examination Survey 2011-2018. Prz Menopauzalny = Menopause Rev.2022; 21: 229–35. https://doi.org/10.5114/PM.2022.123514.
Lee SR, Choi WY, Heo JH, Huh J, Kim G, Lee KP, et al. Progesterone increases blood glucose via hepatic progesterone receptor membrane component 1 under limited or impaired action of insulin. Sci Rep. 2020;10:16316. https://doi.org/10.1038/S41598-020-73330-7.
Karyati S, Astuti P. Usia Menopause dan Kejadian Diabetes Mellitus. J Ilmu Keperawatan Dan Kebidanan. 2016;7:27–31.
Mathew TK, Zubair M, Tadi P. Blood Glucose Monitoring. Med Devices Syst. 2023:66-1-66–10. https://doi.org/10.5005/jp/books/12651_10.
Valentine WJ, Palmer AJ, Nicklasson L, Cobden D, Roze S. Improving life expectancy and decreasing the incidence of complications associated with type 2 diabetes: A modelling study of HbA1c targets. Int J Clin Pract. 2006;60:1138–45. https://doi.org/10.1111/j.1742-1241.2006.01102.x.
Ananda MS, Kurniawati D, Yuandari E. Evaluasi Penggunaan Obat Antidiabetes pada Pasien Diabetes Mellitus Tipe II di Salah Satu Rumah Sakit Swasta di Banjarmasin. Innov J Soc Sci Res. 2023;3:4240–8.
Fasha AA, Kusuma IY, Samodra G. Uji Efek Penurunan Glukosa Darah Dapagliflozin Monoterapi dan Kombinasi dengan Glucose Lowering Agent Lainnya. Pharmacon J Farm Indones. 2021;2021:97–103. https://doi.org/10.23917/pharmacon.v0i0.15839.
PERKENI. Pedoman Pengelolaan dan Pencegahan Diabetes Melitus Tipe 2 Dewasa di Indonesia 2021. PB PERKENI; 2021.
Rizky WA, Annisaa E, Dini IRE. Relationship of OHA’S Treatment Rationality with Therapy Targets Achievement in Type II Diabetes Mellitus Patients. Med Sains J Ilm Kefarmasian. 2024;9:765–70. https://doi.org/10.37874/ms.v9i3.1188.
Downloads
Published
Issue
Section
License
Copyright (c) 2025 Universitas Ahmad Dahlan
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
Authors transfer the copyright and grant the Disease Prevention and Public Health Journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License (CC BY-SA 4.0) that allows others to share (copy and redistribute the material in any medium or format) and adapt (remix, transform, and build upon the material) the work for any purpose, even commercially with an acknowledgement of the work's authorship and initial publication in Disease Prevention and Public Health Journal. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in Disease Prevention and Public Health Journal. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
