Vitamin K and The Immune System

Authors

  • Rachma Greta Perdana Putri Universitas Ahmad Dahlan, Yogyakarta
  • Rosyida Awalia Safitri Department of Nutrition, Faculty of public health , Ahmad Dahlan University, Yogyakarta, Indonesia
  • Yuni Herliyanti Department of Nutrition, Faculty of public health , Ahmad Dahlan University, Yogyakarta, Indonesia

DOI:

https://doi.org/10.12928/admj.v3i1.6237

Abstract

Vitamin K is a vitamin fat-soluble with the main function as an anticoagulant. The active form of vitamin K can be divided into two categories, namely vitamin K1 (phylloquinone) can be found in photosynthetic plants and vitamin K2 (menaquinone) comes from bacteria, source in foods we can found this in fermented foods like natto or soybean product which fermented by Bacillus natto. This literature review was conducted through searching in database like PubMed, and Elsevier using keywords like vitamin K, Immune system, and inflammation. The role of vitamin K in physiological functions is well known worldwide, such as blood coagulation, bone metabolism, and regulation of several types of enzymes. Apart from this role, vitamin K also acts as a cofactor in several plasma proteins, so this vitamin can influence immune responses. Recent studies have found vitamin K links to inflammatory diseases. Vitamin K also induced autophagy pathway. However, information regarding the role of vitamin K in the immune system is limited.

References

Combs, G.F., James P.M. The Vitamins: Fundamental Aspects in Nutrition and Health 5th Ed.

Elsevier Academic Press. 2017.

Shishavan, N. G., & Gargari, B. P. (2019). Vitamin K and Rheumatoid Arthritis. Bioactive Food

as Dietary Interventions for Arthritis and Related Inflammatory Diseases, 161–

doi:10.1016/b978-0-12-813820-5.00008-8

Drouin G, Godin JR, Pagé B. The genetics of vitamin C loss in vertebrates. Curr Genomics.

;12(5):371-378. doi:10.2174/138920211796429736

Booth SL. Vitamin K: food composition and dietary intakes. Food Nutr Res. 2012;56. doi:

3402/fnr.v56i0.5505. Epub 2012 Apr 2. PMID: 22489217; PMCID: PMC3321250.

Kathleen Mahan L., Raymond, J.L. Krause’s Food & The Nutrition Care Process 14th Ed. Elsevier

Academic Press. 2017

Said, H.M., Fayez K.G., Jonathan D.K., et all. Physiology of The Gastrointestinal Tract 6th Ed

Volumes 1 and 2. Elsevier Academic Press. 2018.

Tsugawa N, Shiraki M. Vitamin K Nutrition and Bone Health. Nutrients. 2020; 12(7):1909.

https://doi.org/10.3390/nu12071909

Lacombe J, Ferron M. VKORC1L1, An Enzyme Mediating the Effect of Vitamin K in Liver and

Extrahepatic Tissues. Nutrients. 2018;10(8):970. Published 2018 Jul 26.

doi:10.3390/nu10080970

Hatanaka H, Ishizawa H, Nakamura Y, et al. Effects of vitamin K3 and K5 on proliferation,

cytokine production, and regulatory T cell-frequency in human peripheral-blood mononuclear

cells. Life Sci. 2014;99(1-2):61-68. doi:10.1016/j.lfs.2014.01.068

Pan MH, Maresz K, Lee PS, et al. Inhibition of TNF-α, IL-1α, and IL-1β by Pretreatment of

Human Monocyte-Derived Macrophages with Menaquinone-7 and Cell Activation with TLR

Agonists In Vitro. J Med Food. 2016;19(7):663-669. doi:10.1089/jmf.2016.0030

Abbas, K.A., Andrew H.L., Shiv P. Basic Immunology Functions and Disorders of The Immune

System 6th Ed. 2020. Elsevier

Childs CE, Calder PC, Miles EA. Diet and Immune Function. Nutrients. 2019;11(8):1933.

Published 2019 Aug 16. doi:10.3390/nu11081933

Varghese PM, Murugaiah V, Beirag N, et al. C4b Binding Protein Acts as an Innate Immune

Effector Against Influenza A Virus. Front Immunol. 2021;11:585361. Published 2021 Jan 8.

doi:10.3389/fimmu.2020.585361

Gleeson EM, O'Donnell JS, Hams E, et al. Activated factor X signaling via protease-activated

receptor 2 suppresses pro-inflammatory cytokine production from lipopolysaccharidestimulated myeloid cells. Haematologica. 2014;99(1):185-193.

doi:10.3324/haematol.2013.086918

Checker R, Sharma D, Sandur SK, et al. Vitamin K3 suppressed inflammatory and immune

responses in a redox-dependent manner. Free Radic Res. 2011;45(8):975-985.

doi:10.3109/10715762.2011.585647

Yang RY, Pan JY, Chen Y, Li Y, Wu J, Wang XD. Menaquinone-7 protects astrocytes by regulating

mitochondrial function and inflammatory response under hypoxic conditions. Eur Rev Med

Pharmacol Sci. 2020;24(19):10181-10193. doi:10.26355/eurrev_202010_23239

Lee MH, Yang JY, Cho Y, et al. Inhibitory Effects of Menadione on Helicobacter pylori Growth

and Helicobacter pylori-Induced Inflammation via NF-κB Inhibition. Int J Mol Sci.

;20(5):1169. Published 2019 Mar 7. doi:10.3390/ijms20051169

Ngo ST, Steyn FJ, McCombe PA. Gender differences in autoimmune disease. Front

Neuroendocrinol. 2014;35(3):347-369. doi:10.1016/j.yfrne.2014.04.004

Nakajima, S., Iijima, H., Egawa, S., Shinzaki, S., Kondo, J., Inoue, T.,Hayashi, N.

(2011). Association of vitamin K deficiency with bone metabolism and clinical disease activity in

inflammatory bowel disease. Nutrition, 27(10), 1023–1028. doi:10.1016/j.nut.2010.10.021

Nowak JK, Grzybowska-Chlebowczyk U, Landowski P, et al. Prevalence and correlates of

vitamin K deficiency in children with inflammatory bowel disease. Sci Rep. 2014;4:4768.

Published 2014 Apr 24. doi:10.1038/srep04768

Ekman C, Jönsen A, Sturfelt G, Bengtsson AA, Dahlbäck B. Plasma concentrations of Gas6 and

sAxl correlate with disease activity in systemic lupus erythematosus. Rheumatology (Oxford).

;50(6):1064-1069. doi:10.1093/rheumatology/keq459

Wu J, Ekman C, Jönsen A, et al. Increased plasma levels of the soluble Mer tyrosine kinase

receptor in systemic lupus erythematosus relate to disease activity and nephritis. Arthritis Res

Ther. 2011;13(2):R62. Published 2011 Apr 15. doi:10.1186/ar3316

Recarte-Pelz P, Tàssies D, Espinosa G, et al. Vitamin K-dependent proteins GAS6 and Protein S

and TAM receptors in patients of systemic lupus erythematosus: correlation with common

genetic variants and disease activity [published correction appears in Arthritis Res Ther.

;16(1):404]. Arthritis Res Ther. 2013;15(2):R41. Published 2013 Mar 12.

doi:10.1186/ar4199

Meza-Meza MR, Vizmanos-Lamotte B, Muñoz-Valle JF, et al. Relationship of Excess Weight with

Clinical Activity and Dietary Intake Deficiencies in Systemic Lupus Erythematosus

Patients. Nutrients. 2019;11(11):2683. Published 2019 Nov 6. doi:10.3390/nu11112683

Kaiser R, Taylor KE, Deng Y, et al. Brief Report: Single-nucleotide polymorphisms in VKORC1

are risk factors for systemic lupus erythematosus in Asians. Arthritis Rheum. 2013;65(1):211-

doi:10.1002/art.37751

Duan F, Yu Y, Guan R, Xu Z, Liang H, Hong L. Vitamin K2 Induces Mitochondria-Related

Apoptosis in Human Bladder Cancer Cells via ROS and JNK/p38 MAPK Signal Pathways. PLoS

One. 2016;11(8):e0161886. Published 2016 Aug 29. doi:10.1371/journal.pone.0161886

Dasari S, Ali SM, Zheng G, et al. Vitamin K and its analogs: Potential avenues for prostate cancer

management. Oncotarget. 2017;8(34):57782-57799. Published 2017 May 19.

doi:10.18632/oncotarget.17997

Park GB, Choi Y, Kim YS, Lee HK, Kim D, Hur DY. ROS-mediated JNK/p38-MAPK activation

regulates Bax translocation in Sorafenib-induced apoptosis of EBV-transformed B cells. Int J

Oncol. 2014;44(3):977-985. doi:10.3892/ijo.2014.2252

Karasawa S, Azuma M, Kasama T, et al. Vitamin K2 covalently binds to Bak and induces Bakmediated apoptosis. Mol Pharmacol. 2013;83(3):613-620. doi:10.1124/mol.112.082602

Zhong JH, Mo XS, Xiang BD, et al. Postoperative use of the chemopreventive vitamin K2 analog

in patients with hepatocellular carcinoma. PLoS One. 2013;8(3):e58082.

doi:10.1371/journal.pone.0058082

Frugé AD, Smith KS, Riviere AJ, et al. Primary Outcomes of a Randomized Controlled Crossover

Trial to Explore the Effects of a High Chlorophyll Dietary Intervention to Reduce Colon Cancer

Risk in Adults: The Meat and Three Greens (M3G) Feasibility Trial. Nutrients.

;11(10):2349. Published 2019 Oct 2. doi:10.3390/nu11102349

Downloads

Published

2022-08-23

Issue

Section

Articles