Kaplan Meier's Analysis of Clinical Improvement Of Defecation Frequency In Pediatrics Patient With Diarrhea That Given Vitamin D As Adjuvant Therapy
DOI:
https://doi.org/10.12928/admj.v2i1.3460Keywords:
Diarrhea, Vitamin D, Defecation, Kaplan MeierAbstract
Diarrhea is the second leading cause of death in children under 5 years after pneumonia with a mortality prevalence of 8%. Diarrhea is a digestive disease with signs of bowel movements with a sudden consistency of loose stools 3 times or more in 24 hours, mostly caused by microorganisms (bacteria and viruses). The cure rate for diarrhea after receiving fluid replacement therapy and antibiotics for diarrhea caused by bacteria is quite high, but the mortality rate due to diarrhea is still high, therefore there needs to be an effort to add therapy to improve patient clinical outcomes. Vitamin D is known to play a role in the body's defense function, both in natural and adaptive immunity and plays a role in the body's defense in cases of infections, allergies, and autoimmunity. This study is an experimental double blind randomized clinical trial which was analyzed using Kaplan Meier. The research subjects were children aged 6 months to 18 years who were divided into two groups, namely the treatment group (n = 35) and the control group (n = 35). The treatment group received vitamin D and for the control group received a placebo. The data taken includes the results of the frequency of defecation of patients. The results of this study indicate that vitamin D is effective in accelerating the reduction in the frequency of defecation in children with diarrhea.Â
Keywords: Diarrhea, Vitamin D, Defecation, Kaplan Meier
References
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Kementerian Kesehatan RI. 2012. Profil data Kesehatan Indonesia. Jakarta: Kementerian Kesehatan Republik Indonesia
UNICEF. (2018). Estimates of child cause of death, diarrhoea 2018.
Troeger, C., Khalil, I. A., Rao, P. C., Cao, S., Blacker, B. F., Ahmed, T., Armah, G., Bines, E. J., Brewer, G. T., Colombara, V. D., Kang, G., Kirkpatrick, D. B., Kirkwood, D. C., Mwenda, M. J., Parashar, D. U., Petri, A. W., Riddle, S. M., Steele, D. A., Thompson, L. R., Walson, L. J., Sanders, W. J., Mokdad H. A., Murray, J.L. C., Hay, I. S., Reiner, R. C. (2018). Rotavirus Vaccination and the Global Burden of Rotavirus Diarrhea among Children Younger Than 5 Years. JAMA Pediatrics, 172(10), 958–965.
Dairo, M. D., Ibrahim, T. F., & Salawu, A. T. (2017). Prevalence and determinants of diarrhoea among infants in selected primary health centres in kaduna north local government area, nigeria. Pan African Medical Journal, 28, 1–9.
Dinas Kesehatan Bantul. (2015). Laporan Kinerja Dinas Kesehatan Kabupaten Bantul Tahun 2015, (0274), 1–49.
Bikle, D. D. (2014). Vitamin D metabolism, mechanism of action, and clinical applications. Chemistry & Biology, 21(3), 319–329.
Dusso, A. S., Brown, A. J., & Slatopolsky, E. (2005). Vitamin D. American Physiological Society, 1–86.
Kong, J., Zhang, Z., Musch, M. W., Ning, G., Sun, J., Hart, J., Bissonnette, M., Li, Y. C. (2007). Novel role of the vitamin D receptor in maintaining the integrity of the intestinal mucosal barrier. AJP: Gastrointestinal and Liver Physiology, 294(1), G208–G216.
Kemenkes RI. (2011). Buletin Jendela Data dan Informasi Kesehatan Situasi Diare di Indonesia. Jurnal Buletin Jendela Data & Informasi Kesehatan, 2, 1–44.
Susanti, W. E., Novrikasari, & Sunarsih, E. (2016). Determinan Kejadian Diare Pada Anak Balita Di Indonesia (Analisi Lanjut Data SDKI 2012). Jurnal Ilmu Kesehatan Masyarakat, 7, 64–72.
Talachian, E., Bidari, A., Noorbakhsh, S., Tabatabaei, A., & Salari, F. (2015). Serum levels of vitamins A and D, and zinc in children with acute diarrhea: A cross-sectional study. Medical Journal of the Islamic Republic of Iran, 29.
Thornton, K. A., Marin, C., Mora-plazas, M., & Villamor, E. (2013). Vitamin D Deficiency Associated With Increased Incidence of Gastrointestinal and Ear Infections in School-age Children. The Pediatric Infectious Disease Journal, 32(6), 585–593.
Bener, A., Al-Ali, M., & Hoffmann, G. F. (2009). Vitamin D deficiency in healthy children in a sunny country: Associated factors. International Journal of Food Sciences and Nutrition, 60(SUPPL. 5), 60–70.
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Published
2021-12-29
How to Cite
Kurniawan, N. U., R, S. U., & Darmawan, E. (2021). Kaplan Meier’s Analysis of Clinical Improvement Of Defecation Frequency In Pediatrics Patient With Diarrhea That Given Vitamin D As Adjuvant Therapy. Ahmad Dahlan Medical Journal, 2(1), 34–38. https://doi.org/10.12928/admj.v2i1.3460
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