A rare case of basaloid squamous cell carcinoma in the genital region

Authors

  • Fitria Puspita Dewi Department of Anatomical Pathology, Faculty of Medicine, Universitas Ahmad Dahlan, Yogyakarta, Indonesia
  • Arkan Runako Saputra Department of Obstetrics and Gynecology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr Sardjito Hospital, Yogyakarta, Indonesia

DOI:

https://doi.org/10.12928/admj.v5i2.11461

Keywords:

Basaloid, Squamous cell carcinoma, female, genital

Abstract

Basaloid squamous cell carcinoma (BSCC) is a uncommon variant of squamous cell carcinoma (SCC) with aggressive biological features and frequent distant metastasis1. BSCC is reported to occur in approximately 2% of cases in the head and neck region, such as the oral cavity, larynx and hypopharynx 2,3. BSCC is rarely found in the female genital tract, only 6 cases of BSCC cancer in the genital tract have been reported4. We present the case of a 62-year-old woman who attended to the obstetrics clinic of Dr Sardjito Hospital with multiple blackishmasses on the vulva extending to gluteal region and also lymphadenopathy in the inguinal lymph nodes. A wide excision vulvectomy was performed and the specimen was sent to the Anatomical Pathology Laboratory.

References

Santhosh Manikandan VJ, Krishna PS, Makesh Raj LS, Sekhar P. Basaloid squamous cell carcinoma. J Oral Maxillofac Pathol. 2021 Sep-Dec;25(3):533-536. doi: 10.4103/jomfp.jomfp_382

Gupta B, Bhattacharyya A, Singh A, Sah K, Gupta V. Basaloid squamous cell carcinoma - A rare and aggressive variant of squamous cell carcinoma: A case report and review of literature. Natl J Maxillofac Surg. 2018 Jan-Jun;9(1):64-68. doi: 10.4103/njms.NJMS_14_17.

Linton OR, Moore MG, Brigance JS, Gordon CA, Summerlin D, McDonald MW. Prognostic Significance of Basaloid Squamous Cell Carcinoma in Head and Neck Cancer. JAMA Otolaryngol Head Neck Surg.2013;139(12):1306–1311. doi:10.1001/jamaoto.2013.5308

Lemm M, Słowik Ł, Cichoń B, Poński M, Szwaczka Ł, Bakon I, Witek A. Basaloid squamous cell carcinoma of the uterine cervix coexisting with undifferentiated sarcoma. Prz Menopauzalny. 2020 Dec;19(4):192-194. doi: 10.5114/pm.2020.101944.

Ul Ain, Q., Rao, B. A Rare Case Report: Malignant Vulvar Melanoma. Indian J Gynecol Oncolog 18, 23 (2020). https://doi.org/10.1007/s40944-020-0368-0

Peddapelli K, Rao GV, Sravya T, Ravipati S. Basaloid squamous cell carcinoma: Report of two rare cases and review of literature. J Oral Maxillofac Pathol. 2018 May-Aug;22(2):285. doi: 10.4103/jomfp.JOMFP_98_16.

Salayand S, Haeri H, Ghalehtaki R, Niknejad N, Vaezi M. Non- Metastatic Basaloid Squamous Cell Carcinoma of the Uterine Cervix in a Woman with History of Subtotal Hysterctomy. Int J Cancer Manag. 2017;10(6):e9301. https://doi.org/10.5812/ijcm.9301.

Alkatout, I., Günther, V., Schubert, M., Weigel, M., Garbrecht, N., Jonat, W., & Mundhenke, C. (2015). Vulvar cancer: epidemiology, clinical presentation, and management options. International Journal of Women’s Health, 305.doi:10.2147/ijwh.s6897

Jain N, Raut T, Keshwar S, Shrestha A, Jaisani MR, Paudel D. Histopathological Characterization of a Series of Oral Basaloid Squamous Cell Carcinoma. Hindawi. Case Report in Dentistry. 2023. April(1). https://doi.org/10.1155/2023/6036567

Wohlmuth C, Wohlmuth-Wieser I. Vulvar malignancies: an interdisciplinary perspective. J Dtsch Dermatol Ges. 2019 Dec;17(12):1257-1276. doi: 10.1111/ddg.13995

Schuurman MS, van den Einden LC, Massuger LF, Kiemeney LA, van der Aa MA, de Hullu JA. Trends in incidence and survival of Dutch women with vulvar squamous cell carcinoma. Eur J Cancer. 2013 Dec;49(18):3872-80. doi: 10.1016/j.ejca.2013.08.003

Chokoeva AA, Tchernev G, Castelli E, Orlando E, Verma SB, Grebe M, Wollina U. Vulvar cancer : a review for dermatologist. Wien Med Wochenschr. 2015. doi: 10.1007/s10354-015-0354-9

Sagdeo A, Gormley RH, Abuabara K, Rady P, Elder ED, Kovarik CL. The diagnostic challenge of vulvar squamous cell carcinoma : clinical manifestations and unusual human papilonavirus types. Journal of the American Academy of Dermatology. 2014 (70): 3. P586-588.

Stana MM, Deac S, Cainap C, Achimaș-Cadariu P, Bota M, Resiga L, Luchian DȘ, Bochiș OV. What to do when nothing else is left to be done - metastatic non-HPV vulvar squamous cell carcinoma with multiple lines of chemotherapy. Arch Clin Cases. 2021 Dec 29;8(3):50-55. doi: 10.22551/2021.32.0803.10186

Namuduri RP, Lim TY, Yam PK, Gatsinga R, Lim-Tan SK, Chew SH, Koh MJ, Mansor S. Vulvar basal cell carcinoma: clinical features and treatment outcomes from a tertiary care centre. Singapore Med J. 2019 Sep;60(9):479-482. doi: 10.11622/smedj.2019014

Hashim M, Yayanto NH, Muda Abdullah BZ, Ramly F, Abd Rashid R, Duski DR. Vulvar malignant melanoma: A case report and review of its management. Dermatol Reports. 2022 Jul 4;14(4):9345. doi: 10.4081/dr.2022.9345

Heera R, Ayswarya T, Padmakumar SK, Ismayil P. Basaloid squamous cell carcinoma of oral cavity: Report of two cases. J Oral Maxillofac Pathol. 2016 Sep-Dec;20(3):545. doi: 10.4103/0973-029X.190964

Downloads

Published

2024-11-30

How to Cite

Fitria Puspita Dewi, & Saputra, A. R. . (2024). A rare case of basaloid squamous cell carcinoma in the genital region. Ahmad Dahlan Medical Journal, 5(2), 220–227. https://doi.org/10.12928/admj.v5i2.11461

Issue

Section

Case Report